I am a proud user of Adobe Fireworks. I would argue that there is no software so well aimed at the web development market. Sure Photoshop does cool stuff, and I use that for advanced graphics, but for mocking up a GUI, nothing comes close.
Which is nice. After a year and a half. After I’ve sent 5+ detailed emails to Adobe, yet recieved no response. Now, I bought CS4 under the student license for £400, so I don’t have quite as much right to be annoyed as those who spend £2000 on the suite. But still, when users complain about text bugs, and Adobe say “What are you using text for in a graphics program?”, it doesn’t inspire confidence that the company even understands their product.